Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.
Experiencia docente
Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.
Experiencia profesional
1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.
Acreditaciones, habilitaciones y reconocimientos
Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
Evaluación positiva PEP-ANECA para las figuras de:
Profesor Contratado Doctor
Profesor Ayudante Doctor
Profesor de Universidad Privada
En el ámbito docente e investigador del sistema universitario español.
Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.
Actividad investigadora
Líneas de investigación
Biomateriales.
Ingeniería tisular.
Medicina regenerativa.
Terapia génica.
Inmunología.
Participación en proyectos
"Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
"Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
"Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
"Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
"Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
"Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
"Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
"Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
"Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
"Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
"Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
"Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
"Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
"Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
"Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
"Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
"Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
"Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
"Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
"Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
"Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
"A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
"Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
"Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
"Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
"Multifunctional materials for society challenges (MULTIMAT-CHALLENGE). S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
"Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
"NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
"Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
"Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.
Publicaciones
Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY. (2016). Pages 281-92.
F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa. "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
