• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia

• Doctorado en Bioquímica y Biología Molecular. Universidad Complutense, Madrid, España.
• Diploma de Estudios Avanzados. Universidad Complutense, Madrid, España.
• Máster en Instrumentación Biomédica y Tecnología (750 h). Universidad Nacional de Educación a Distancia.
• Licenciatura en Biología (especialidad Biosanitaria) Universidad Complutense, Madrid, España.

• Módulo de Fisiopatología General. Curso Técnico Superior Laboratorio Clínico Biomédico. Curso 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Gestión de Muestras Biológicas. Curso Técnico Superior Laboratorio Clínico Biomédico 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Anatomofisiología y Patología Básicas. Curso Técnico en Farmacia y Parafarmacia 2020-2021. IES Villaverde. Madrid, España.
• Módulo de Organización y Gestión de la Unidad de Salud Ambiental. Curso Técnico Superior en Salud Ambiental 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Módulo de Oficina de Farmacia. Curso Técnico en Farmacia y Parafarmacia 2019-2020. IES Benjamín Rúa. Móstoles, Madrid, España.
• Conversión fototérmica de energía infrarroja en medicina regenerativa y terapias avanzadas. Programa de actualización en investigación biomédica. Instituto de Salud Carlos III, Majadahonda, Madrid, España. Febrero 2018.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en biomedicina. XIV Curso de ac-tualización en investigación traslacional. Hospital Universitario Puerta de Hierro, Majadahonada, Ma-drid, España. Marzo 2017.
• Conversión fototérmica de energía infrarroja para terapias avanzadas en medicina regenerativa. XV Cur-so sobre biomateriales y el entorno celular. CSIC-Hospital Nuestra Señora de Sonsoles, Ávila. Febrero 2017.

• 1/07/2021‐Actualidad: Funcionario en Prácticas. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 1/09/2020-30/06/2021: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Sanitarios. CAM.
• 30/09/2019‐31/08/2020: Funcionario Interino. Cuerpo de Profesores de Enseñanza Secundaria. Especialidad Procesos Diagnósticos Clínicos y Productos Ortoprotésicos. CAM.
• 12/2016‐31/05/2019: Investigador postdoctoral senior. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 12/2013‐11/2016: Investigador postdoctoral senior. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España.
• 07/2012‐11/2013: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2011‐06/2012: Investigador postdoctoral en la University of Michigan, Ann Arbor, MI, EEUU
• 01/2010‐12/2011: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España
• 03/2008‐12/2009: Investigador postdoctoral. Centro de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España
• 10/2007‐03/2008: Investigador postdoctoral. Hospital Universitario La Paz-IdiPAZ, Madrid, España.
• 09/2006‐07/2007: Investigador postdoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2001‐06/2006: Investigador predoctoral. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
• 06/2000‐05/2001: Colaborador en prácticas. Departamento de Microbiología, Facultad de Biología. Universidad Complutense, Madrid, España.

• Habilitación lingü.ística en lengua inglesa, para el desempeño de puestos bilingües en el ámbito de los centros docentes públicos y privados de la Comunidad de Madrid.
• Evaluación positiva PEP-ANECA para las figuras de:
  • Profesor Contratado Doctor
  • Profesor Ayudante Doctor
  • Profesor de Universidad Privada
• En el ámbito docente e investigador del sistema universitario español.
• Licencia de función "D" (categoría C) para la planificación independiente, implementación y toma de responsabilidad en el diseño de procedimientos de experimentación animal según lo dispuesto por la directiva Europea 2010/63/EU artículo 23.2. Hospital Universitario Ramón y Cajal. Madrid, España.
• Acreditación en el programa de entrenamiento postdoctoral para la investigación biomédica adscrita a universidad estadounidense. The University of Michigan, Ann Arbor, MI, EEUU.
• Certificado de Aptitud Pedagógica. Universidad Complutense, Madrid, España.

Líneas de investigación

• Biomateriales.
• Ingeniería tisular.
• Medicina regenerativa.
• Terapia génica.
• Inmunología.

Participación en proyectos

• "Biomedical Research Network of Neurologic diseases" (Group III, ISCIII Node). Health Research Fund (Spain) FIS Networking nº C03/06 (2003-2005). Principal investigator: Dr. Jesus de Pedro.
• "Regulation of genes involved in T helper lymphocytes activity. Beta Interferon Influence." Ministry of Science and Technology, Spain (Biomedicine National Plan) SAF2003-00189. (2003-2005). Principal investigator: Dr. Sara Ballester
• "Phosphodiesterase 7 inhibition as ant-inflammatory therapy in a multiple sclerosis animal model." MM Foundation for Biomedical Research. (2004-2007). Principal Investigator: Dr. Sara Ballester.
• "Molecular basis for the anti-inflammatory effect of Beta-Interferon and the phosphodiesterases inhibition. Influence in the gene expression of T lymphocytes and involvement in a multiple sclerosis animal model". Carlos III Health Institute, Spain. (2005-2008). Principal Investigator: Dr. Sara Ballester.
• "Influence of Beta interferon in T lymphocytes gene expression. Possible implications in the multiple sclerosis treatment response". Health Research Fund (Spain) FIS MPY1358/06 (2006-2009). Principal Investigator: Dr. Sara Ballester.
• "Immunomodulation of inflammation by beta Interferon and simvastatine potential cooperation: consequences in Regulatory T cells, IL-17 production and astrocyte activity". MM Foundation for Biomedical Research MPY-1156/07 (2007-2010). Principal Investigator: Dr. Sara Ballester.
• "Third-generation biomaterials and intelligent biomaterials", S-0505/MAT/OOO324 CAM (Community of Madrid) Networking, Spain (2006-2009). Principal Investigator: Dr. Luis Munuera.
• "Development of a new gene therapy system for the control of the spatial and temporal expression of HSVtk y GALV in tumoral cells." MM Foundation for Biomedical Research, Spain (2007-2010) Principal Investigator: Dr. Nuria Vilaboa.
• "Development of new scaffold concepts and cell cultures for regenerative medicine (BIO-SCAFF, Bone SubProject)". Carlos III Health Institute, Intramural Project CIBER-BBN, Spain (2008-2009). Coordinator: Dr. Josep Planell.
• "Synthesis and characterization of adapted magnetic nanoparticles stables in biological media (NANOMAG)". Carlos III Health Institute, Intramural CIBER-BBN project, Spain (2008-2009). Coordinator: Prof. Frco. del Pozo.
• "Silica and magnetic nanoparticles use in gene therapy and hyperthermia". MM Foundation for Biomedical Research, Spain (2008-2010). Principal Investigator: Dr. Nuria Vilaboa.
• "Application of ion implantation on the development of bioactive metallic biomaterials with antibacterial properties (BIOBAC)". Ministry of Science and Innovation, Spain (2008). Coordinator: Dr. José Luis González-Carrasco.
• "Improvement of the biological behavior and mechanical properties of conventional metallic alloys by combining novel surface modifications (BIOCOATING)". Ministry of Science and Innovation, Spain (2009-2012). Coordinator: Dr. M. Luisa González.
• "Biomimetic extracellular matrices for angiogenic activation and anti- inflammatory activity in regenerative medicine (BIOGELANGIO)". Carlos III Health Institute (CIBER-BBN SubProject), Spain 2010-2013. Coordinator: Dr. Julio San Roman
• "Development of new nanoparticles and protocols for enhanced hyperthermia (NANOHYPERTHERMIA)". Carlos III Health Institute (CIBER-BBN Subproject), Spain (2010-2011). Coordinator: Prof. Fco. del Pozo.
• "Nano-engineering inclusion bodies as new biomaterials for cell proliferation (NAINBO)". Carlos III Health institute (CIBER-BBN SubProject), Spain 2010-2011. Coordinator: Dr. Antonio Villaverde
• "Cell Mechanics: understanding mechanotransduction and cell-substrate interaction mechanisms. Applications in cell therapy and tissue engineering. (CELL MECHANICS)". Carlos III Health Institute (CIBER-BBN SubProject), Spain (2010-2011). Coordinator: Manuel Doblaré.
• "Improvement of culture techniques for human mesenchymal cells in a perfusion bioreactor. Application in bone tissue engineering". MM Foundation for Biomedical Research, Spain (2010-2012). Principal Investigator: Dr. Nuria Vilaboa.
• "Phototherapy: gold nanoparticles for the thermal ablation of tumor cells and for the activation of therapeutic genes (PHOTOTHERAPY)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2012-2013. Principal Investigator: Dr. Manuel Arruebo.
• "Phototherapy: plasmonic gold nanoparticles for the phototermic ablation of tumor cells and activation of therapeutic genes" Ramon Areces Foundation. Principal Investigator: Dr. Manuel Arruebo. 2010-2011.
• "Combinatorial Gene Therapy for Bone Regeneration" DE13386, National Institutes of Health (NIH, USA). Principal Investigator: Renny T. Franceschi
• "A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors" W81XWH-10-1-0992, Department of Defense (DOD, USA). Principal Investigator: Renny T. Franceschi.
• "Aplication of a novel gene therapy system for spatiotemporal "Aplication of a novel gene therapy system for spatiotemporal control of the bioavailability of growth factors involved in bone regeneration." Health Research Fund (Spain) FIS PI12/01698. Principal Investigator: Nuria Vilaboa. 2013-2015.
• "Plasmonic scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2014-2015. Principal Investigator: Nuria Vilaboa.
• "Spatiotemporal control of transgene expression by near infrared light (INFRAGEN)". Ministry of Economy and Competitiveness, Spain 2014-2016. Principal Investigator: Nuria Vilaboa.
• "Multifunctional materials for society challenges (MULTIMAT-CHALLENGE).  S2013/MIT-2832. Community of Madrid, Spain. 2014-2018. Coordinator: Elena Gordo.
• "Advanced therapy for bone regeneration: tissue intermediates induced by infrared energy for the controlled expression of osteogenic and angiogenic growth factors" Health Research Fund (Spain) FIS 2016-2018. Principal Investigator: Nuria Vilaboa.
• "NIR-responsive scaffolds for deliberate regulation of transgene expression in bone tissue engineering (HOT-SCAFF Extended)" Carlos III Health institute (CIBER-BBN SubProject), Spain 2016-2017. Principal Investigator: Nuria Vilaboa.
• "Animal model of bone regeneration induced by tissue intermediates responsive to near-infrared light (AMBIT)." Roche pharma-IdiPAZ grant 2016. Principal Investigator: Nuria Vilaboa.
• "Preparation and application of eardrops for the inhibition of sensorineural hearing loss produced by ototoxic therapeutic agents (NADEAFNESS). CIBER-BBN technology transfer program 2017-2019. Coordinator: Mª Rosa Aguilar.

Tramos de investigación (Sexenios)

• Dorado B., Jerez M.J., Flores N., Martín-Saavedra FM., Durán C. and Ballester S. "Autocrine IL-4 negatively regulates its own expression in TCR-activated Th2 cells". Journal of Immunology (2002). 169:3030-37. IFJCR2002= 7.014
• Cuni S., Pérez-Aciego P., Pérez-Chacón G., Vargas J.A., Sánchez A., Martín-Saavedra FM, Ballester S., García-Marco J., Jordá J., Durantez A.. "A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells". Leukemia (2004). 18:1391-400. IFJCR2004= 5.810
• Dorado B., Martín-Saavedra F.M., Jerez J.M. and Ballester S. Molecular. "The activity of interleukin-4 receptor alpha-chain promoter is regulated by a GT box element". Molecular Immnunology (2006). 43:1808-16. IFJCR2006=4.768
• Martín-Saavedra F.M., Flores N., Dorado B., Eguiluz C., Bravo B., García-Merino A. and Ballester S., "Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis". Molecular Immunology (2007). 44:3597-607. IFJCR2007= 3.742
• Martín-Saavedra FM, González C., Bravo B., and Ballester S. "Beta Interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells" Molecular Immunology (2008). 45:4008-19. IFJCR2008=3.555
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat and rapamycin-based gene switches for spatial and temporal control of transgenes". Human Gene Therapy. (2008). 10:19 1100-01. IFJCR2008= 4.104
• Martín-Saavedra F.M., Boré A., Voellmy R., Vilaboa N. "Heat-activated, rapamycin-dependent gene switches for tight control of transgene expression". Human Gene Therapy. (2009) 20:1060-1061. IFJCR2009=4.202
• González C., Martín-Saavedra F.M., and Ballester S. "Th17 lineage: answers to some immunological questions". Inmunologia. (2009). 28:32-45.
• Martín-Saavedra FM, Ruiz-Hernández E, Boré A, Arcos D, Vallet-Regí M, Vilaboa N. "Magnetic mesoporous silica spheres for hyperthermia therapy". Acta Biomaterialia (2010). 6:4522-31. IFJCR2010=4.824
• Virginia Cebrián, Clara Yagüe, Manuel Arruebo, Francisco M. Martín-Saavedra, Jesús Santamaría and Nuria Vilaboa. "On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors" Journal of Nanoparticle Research (2011). 9:4097-108. IFJCR2011=3.287
• Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. "Size-dependent transfection efficiency of PEI-coated gold nanoparticles" Acta Biomateralia (2011). 7:3645-55. IFJCR2011=4.865
• Vallés G., Pérez C., Boré A., Martín-Saavedra F., Saldaña L., Vilaboa N. "Simvastatin prevents the induction of interleukin-6 (IL-6) gene expression by titanium particles in human osteoblastic cells." Acta Biomateralia (2012). 9:4916-25. IFJCR2011=5.093
• Martín-Saavedra, F.M., Wilson, C., Voellmy, R., Vilaboa, N., Franceschi, R. "A heat-activated and ligand-dependent gene switch for the spatiotemporal control of regenerative transgenes". Human Gene Therapy (2012). 23:A85 IFJCR2012=4.019
•  Cebrián V., Martín-Saavedra F.M., Leyre Gómez., Arruebo M., Santamaría J., Vilaboa N. "Enhancing of plasmonic photothermal therapy through heat-inducible transgene activity". Nanomedicine: Nanotechnology, Biology and Medicine (2013). 9:646-56. IFJCR2013=5.978
• Leyre Gómez, Virginia Cebrián, Francisco Martín-Saavedra, Manuel Arruebo, Nuria Vilaboa, Jesús Santamaría. "Colloidal stability and biocompatibility of gold nanorods for photothermal therapy". Material Research Bulletin (2013). 48:4051-57. IFJCR2013=1.968
• C.G. Wilson, F.M. Martín-Saavedra, N. Vilaboa-Díaz, R. T. Franceschi. "Advanced BMP gene therapies for temporal and spatial control of bone regeneration." Journal of Dental Research (2013). 5:409-17. IFJCR2013=4.144
• Mario L. Fabiilli, Christopher G. Wilson, Frédéric R. Padilla, Francisco M. Martín-Saavedra, J. Brian Fowlkes, Renny T. Franceschi. "Acoustic droplet-hydrogel composites for on-demand delivery of growth factors and control of scaffold properties." Acta Biomateralia (2013). 9:7399-409. IFJCR2013=5.684
• Martín-Saavedra FM, Wilson C.G., Vilaboa N., Voellmy R., Franceschi R.T. "Spatiotemporal control of vascular endothelial growth factor expression using a heat shock and rapamycin-dependent gene switch." Human Gene Therapy Methods (2013). 24:160-70. IFJCR2013=1.641
• Wilson, C.G., Martín-Saavedra, F.M., Padilla, F., Fabiilli, M.L., Zhang, M., Baez, A.M., Bonkowski, C.J., Kripfgans, O.D., Voellmy, R., Vilaboa, N., Fowlkes, B. y Franceschi, R.T. "Patterning expression of regenerative growth factors using high intensity focused ultrasound." Tissue Eng part C. (2014) 10:769-79. IFJCR2014=4.448
• Martín-Saavedra, F.M., Cebrián, V., Gómez, L., López, D., Arruebo, M., Wilson, C.G., Franceschi, R.T., Voellmy, R., Santamaría, J. y Vilaboa, N. "Temporal and spatial patterning of transgene expression by near-infrared irradiation." Biomaterials (2014). 28:8134-43. IFJCR2014=8.557
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Vilaboa. "Temporospatial Control of Growth Factor Bioavailability Mediated by Biodegradable Semiconductor Hydrogels". Tissue Engineering: Part A (2015). 21:S240. IFJCR2015=3.892
• L. Crespo, F. Martín-Saavedra, L. Saldaña, E. Gómez-Barrena, N. Vilaboa. "The Paracrine Relationships that Mesenchymal Stem Cells Establish with Osteoblast and Endothelial Cells are Influenced by Biomaterials Features". Tissue Engineering: Part A (2015). 21:S270. IFJCR2015=3.892
• Martin-Saavedra F, Vilaboa N. (2016) "Remote Patterning of Transgene Expression Using Near Infrared-Responsive Plasmonic Hydrogels" in Kianianmomeni A. (ed.) Optogenetics. Methods in Molecular Biology, vol 1408. Humana Press, New York, NY.  (2016). Pages 281-92.
• F.M. Martín-Saavedra, C. Escudero, M. Prieto, M. Arruebo, J. Santamaría, N. Sadeghi, R. Deckers, G. Storm, W.E. Hennink, E. Ruiz-Hernández, N. Vilaboa. "Plasmonic Lipogels Responsive to Near Infrared Light for Remote Control of Drug Release." Tissue Engineering: Part A (2015). 21:S374. IFJCR2015=3.892
• Vilaboa N, Bore A, Martín-Saavedra F, Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R. "New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival." Nucleic Acids Research (2017). 10:5797-5817. IFJCR2015=10.162
• Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J. "Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780." Acta Biomaterialia (2017) 57:70-84. IFJCR2016=6.319
• Martín-Saavedra F*, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N. "Lipogels responsive to near-infrared light for the triggered release of therapeutic agents." Acta Biomaterialia (2017) 61:54-65. IFJCR2016=6.319
• Martín-Saavedra F, Crespo L, Escudero-Duch C, Saldaña L, Gómez-Barrena E, Vilaboa N. "Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts." Scientific Reports (2017) 7:15812. IFJCR2016=4.259
• Martín-Saavedra F*, Escudero-Duch C, Prieto M, Sánchez-Casanova S, López D, Arruebo M, Voellmy R, Santamaría J, Vilaboa N. "Pro-angiogenic near infrared-responsive scaffolds for patterning the expression of therapeutic transgenes". Acta Biomaterialia (2018). 78:123-136. IFJCR2018=6.638
• Silvia Sanchez-Casanova, Francisco M Martin-Saavedra*, Clara Escudero-Duch, Maria I Falguera Uceda, Martin Prieto, Manuel Arruebo, Paloma Acebo, Mario L Fabiilli, Renny T Franceschi, Nuria Vilaboa.  "Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration." Biomaterials (2020). 241:119909. IFJCR2020=10.317
• Alberto Nakal-Chidiac, Olga García, Luis García-Fernández, Francisco M Martín-Saavedra, Silvia Sánchez-Casanova, Clara Escudero-Duch, Julio San Román, Nuria Vilaboa, María Rosa Aguilar. "Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties" Carbohydrate polymers (2020). 250:116973. IFJCR2020=7.182
*= Como autor de correspondencia